Microfragmented Adipose Tissue for Joint Pain: A Modern Nonsurgical Option

If joint pain is limiting your activity, interrupting your sleep, or keeping you from moving the way you want to move, you may be exploring options beyond medication or surgery. Microfragmented adipose tissue, also known as MFAT, is one of the orthobiologic treatments we offer for select patients who want a personalized, nonsurgical strategy to support comfort and mobility.

MFAT uses a small sample of a patient’s own adipose tissue, processed during the same procedure, and then reinjected under image guidance into the area of concern. It is considered investigational in orthopedic care, and ongoing research continues to study where it may fit within the spectrum of nonsurgical treatment options.

What MFAT Involves

MFAT is created from a patient’s own adipose tissue collected from areas such as the abdomen or flank. The tissue is mechanically processed, without enzymes or cell isolation, using FDA-compliant minimal manipulation techniques. This approach preserves the natural structure of the adipose tissue while preparing it for same-day use.

The prepared tissue is then injected into the joint or soft tissue region under ultrasound guidance for precision and comfort. The entire visit typically takes between one and two hours, and most patients walk out of the clinic shortly afterward.

How MFAT Differs From Donor Products Often Marketed as “Stem Cell Therapy”

Patients often ask how MFAT compares to products marketed as stem cell treatments. MFAT is created entirely from a patient’s own tissue during the same procedure, using minimal manipulation techniques that align with FDA guidance.

Many donor-derived products, such as those obtained from umbilical cord or placental tissue, are not FDA-approved for orthopedic use and cannot be marketed for joint or tendon problems. These products involve donor biologics and may undergo processing methods that fall outside the FDA definition of minimal manipulation.

MFAT does not involve cell isolation, expansion, or enzyme digestion. It is an autologous orthobiologic option used in select cases after careful evaluation. During consultation, we discuss all available pathways so patients understand what is investigational, what aligns with regulatory standards, and what best fits their goals.

Why Some Patients Explore MFAT

Many patients come to us after trying multiple nonsurgical treatments, including physical therapy, activity modification, or steroid injections. MFAT may be considered for individuals who:

• Want options that use their own tissue
• Hope to delay or avoid more invasive surgical procedures
• Prefer treatments that fit into an active lifestyle
• Have not achieved their goals with other conservative approaches

MFAT is not FDA-approved for the treatment of arthritis or tendon injuries, and results vary from person to person. It is one option in a broader toolbox, and part of our role is determining whether it is appropriate for your specific condition.

Conditions Where MFAT May Be Considered

MFAT may be discussed as part of a treatment plan for:

• Knee, hip, or shoulder discomfort
• Wear-related joint symptoms
• Soft tissue irritation that has not responded to traditional care
• Chronic joint pain affecting mobility or function

Not every patient is a candidate. A thorough evaluation helps clarify whether MFAT, or another treatment such as physical therapy, PRP, BMAC, or surgery, is the most appropriate choice.

What Recovery Looks Like

After an MFAT procedure, patients can expect:

• Mild soreness at the collection or injection sites for several days
• A short period of activity modification
• Gradual return to normal activity as guided by the clinical team

Most individuals resume light daily activity within a day or two, with changes in comfort and mobility occurring gradually over the following weeks.

Because MFAT is investigational, treatment expectations are individualized rather than standardized. We discuss your goals in detail so that your plan aligns with your activity level and functional needs.

A Whole-Person, Precision-Based Approach

What makes care at Form & Function Orthopaedics different is not any single procedure, but how each treatment fits into a larger, personalized strategy. For many midlife adults, the goal is not simply pain relief. It is staying active, maintaining strength, and preserving joint function for the long term.

MFAT is one of several tools we may consider, alongside rehabilitation, orthobiologic injections, load management strategies, and when appropriate, surgical options. Our focus is finding the combination that supports your movement, lifestyle, and long-term performance.

Is MFAT the Right Option for You

The best next step is a consultation. We will review your history, examine the involved area, discuss imaging, and explore your activity goals. From there, we determine whether MFAT is appropriate or whether another pathway offers a clearer benefit.

Take the Next Step

If joint pain has been holding you back, whether in your workouts, your work, or your everyday life, we are here to help you explore thoughtful, personalized, and modern treatment options.

To schedule a consultation, visit f2ortho.com or call our office.

We serve patients throughout Portland, Lake Oswego, Beaverton, Tigard, and the surrounding communities.